Journal article
PDTM-21. MATCHING OF SINGLE CELL TRANSCRIPTOMICS FROM CEREBELLAR DEVELOPMENT IDENTIFIES PUTATIVE SUBGROUP SPECIFIC CELLS OF ORIGIN FOR MEDULLOBLASTOMA
Abstract
Abstract We isolated cells from various points in murine embryonic and early post-natal cerebellar development (E10 to P14) and undertook single cell RNA sequencing to identify >30 transcriptionally distinct cell populations. Reconstruction of developmental lineages in the developing cerebellum through pseudotemporal analysis demonstrate that a progenitor cell population from the upper rhombic lip gives rise to both the external granule cell …
Authors
El-Hamamy I; Vladoiu M; Donovan L; Cavalli F; Ramaswamy V; Farooq H; Lopez B; Kleinman C; Chan J; Singh S
Journal
Neuro-oncology, Vol. 20, No. Suppl 6, pp. vi208–vi208
Publication Date
November 2018
ISSN
1522-8517