Journal article
A translational pharmacokinetic/pharmacodynamic approach supports optimal vonoprazan dosing for erosive oesophagitis and Helicobacter pylori infection
Abstract
BACKGROUND: Treatment of acid-related disorders relies on gastric acid suppression. The percentage of time intragastric pH is >4 (pH >4 holding time ratio [HTR]) is important for healing erosive oesophagitis; and the pH >6 HTR is critical for eradication of Helicobacter pylori infection, as bacterial replication is active and antibiotic effectiveness is optimised. Vonoprazan, a potassium-competitive acid blocker approved in the USA and other …
Authors
Scarpignato C; Howden CW; Leifke E; Mulford DJ; Lahu G; Facius A; Hunt R
Journal
Alimentary Pharmacology & Therapeutics, Vol. 58, No. 1, pp. 16–25
Publisher
Wiley
Publication Date
July 2023
DOI
10.1111/apt.17510
ISSN
0269-2813