Journal article
Abstract LB130: Combination of IGF-1R targeted alpha therapy with Olaparib results in synergistic efficacy against colorectal and lung cancer xenografts
Abstract
Abstract
Objectives: FPI-1434 is a targeted alpha-particle therapeutic consisting of an IGF-1R targeting antibody radiolabeled with Actinium-225. The primary mechanism of action for FPI-1434 is induction of double strand DNA breaks (DSB) in targeted tumors resulting in cell death. Poly (ADP-ribose) polymerase (PARP) is part of the cellular mechanism that repairs DSB. In cancer patients with genetic defects in DSB repair (eg. …
Authors
Hu M; Forbes J; Simms R; Storozhuk Y; Burak E; Valliant J
Journal
Cancer Research, Vol. 81, No. 13_Supplement, pp. lb130–lb130
Publisher
American Association for Cancer Research (AACR)
Publication Date
July 1, 2021
DOI
10.1158/1538-7445.am2021-lb130
ISSN
0008-5472