Abstract LB155: Combination of IGF-1R targeted alpha therapy with checkpoint inhibitors results in synergistic efficacy in a syngeneic colorectal tumor model

Abstract Objective: In the last decade, immunotherapy has revolutionized cancer care and became a mainstream therapy along with surgery, chemotherapy and radiation. Unfortunately, only a limited number of cancers exhibit intrinsic sensitivity to immunotherapies and the overall response rate is only 20-25%. Therefore, there is a strong impetus to identify treatments which can sensitize patients to immunotherapies. Fusion …