Evidence for a Th2-to-Th1 shift in IL-4 deficient mice in response to chronic house dust mite exposure

RationaleIL-4 is an important mediator in the development of Th2-type inflammation in the airway. We therefore examined the response of IL-4 deficient (4KO) mice to chronic house dust mite (HDM) exposure, a protocol that results in a Th2-skewed response in wild type (WT) mice.MethodsHDM was administered intranasally for five consecutive weeks. After full resolution of this inflammatory response, mice were rechallenged on five consecutive days …