Exercise‐Induced Amelioration of Diet‐Induced Obesity and Diabetes is Not Regulated by Irisin

Physical inactivity is a primary modifiable risk factor for obesity and type 2 diabetes (T2D) – metabolic diseases that are rampant in pediatric and adult population. Endurance exercise has been shown to prevent and/or attenuate the onset and progression of obesity and T2D. The myokine 'irisin' (cleaved product of Fndc5 in response to endurance exercise) has been touted to play a role in this process but the data available thus far is …