Chapter
Myeloid-Derived Suppressor Cells in Aged Humans
Abstract
Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells whose immunosuppressive activities contribute to cancer and other diseases. MDSCs appear to increase with age, and this presumably contributes to immunosuppression and the increased incidence of certain diseases. Why MDSCs increase with age is not entirely clear. Herein we present evidence that MDSC expansion is due in part to age-related changes in hematopoiesis, including the …
Authors
Rauh MJ; Cook EK; Bowdish DME
Book title
Handbook of Immunosenescence
Pagination
pp. 1-12
Publisher
Springer Nature
Publication Date
2018
DOI
10.1007/978-3-319-64597-1_96-1