Journal article
Augmented Parkin-dependent mitophagy underlies the hepatoprotective effect of remote ischemic conditioning used prior to hemorrhagic shock
Abstract
BACKGROUND AND AIMS: Hemorrhagic shock-resuscitation (HSR) following trauma contributes to organ dysfunction by causing ischemia-reperfusion injury (IRI). We previously showed that 'remote ischemic preconditioning' (RIPC) exerted multi-organ protection from IRI. Maintenance of mitochondrial quality by clearance of dysfunctional mitochondria via mitophagy is vital in restoring organ integrity. We hypothesized that parkin-dependent mitophagy …
Authors
Naraiah Mukkala A; Petrut R; Goldfarb R; Leigh Beroncal E; Ho Leung C; Khan Z; Ailenberg M; Jerkic M; Andreazza AC; Rhind SG
Journal
Mitochondrion, Vol. 70, , pp. 20–30
Publisher
Elsevier
Publication Date
5 2023
DOI
10.1016/j.mito.2023.03.002
ISSN
1567-7249