1312P The Relationship Between Egfr and Kras Mutation Status and Overall Survival (Os) in the Ncic Ctg Br.26 Randomized Trial of Dacomitinib (D) Versus Placebo (P) in Patients with Previously Treated Non Small Cell Lung Cancer (Nsclc)

Aim: Dacomitinib (D) is an irreversible, pan Her inhibitor with activity in NSCLC previously treated with an EGFR TKI. Methods: BR26 was a randomized placebo controlled trial of D (45mg orally daily) versus P in NSCLC patients previously treated with chemotherapy and an EGFR TKI. The primary outcome was OS. Secondary outcomes included PFS and OS in patients with KRAS wild type (WT) and EGFR mutated (mut) tumors, response rate (RR), toxicity and …