Journal article
Intrinsic BMP inhibitor Gremlin regulates alveolar epithelial type II cell proliferation and differentiation
Abstract
Type 1 alveolar epithelial cells (AT1s) and type 2 alveolar epithelial cells (AT2s) regulate the structural integrity and function of alveoli. AT1s mediate gas exchange, whereas AT2s serve multiple functions, including surfactant secretion and alveolar repair through proliferation and differentiation into AT1s as progenitors. However, mechanisms regulating AT2 proliferation and differentiation remain unclear. Here we demonstrate that Gremlin, …
Authors
Yanagihara T; Zhou Q; Tsubouchi K; Revill S; Ayoub A; Gholiof M; Chong SG; Dvorkin-Gheva A; Ask K; Shi W
Journal
Biochemical and Biophysical Research Communications, Vol. 656, , pp. 53–62
Publisher
Elsevier
Publication Date
5 2023
DOI
10.1016/j.bbrc.2023.03.020
ISSN
0006-291X