Journal article
CLASSIC IL-6 SIGNALING IS ASSOCIATED WITH POOR OUTCOMES IN BURN PATIENTS
Abstract
ABSTRACT: Background: Interleukin (IL)-6 is a multifunctional cytokine with both a proinflammatory and anti-inflammatory role. In many studies, IL-6 increases rapidly after burn injury and is associated with poor outcomes. However, there are two aspects to IL-6; it can signal via its soluble IL-6 receptor (sIL-6R), which is referred to as trans-signaling and is regarded as the proinflammatory pathway. The role of sIL-6R postburn injury has yet …
Authors
Rehou S; Abdullahi A; Jeschke MG
Journal
Shock, Vol. 59, No. 2, pp. 155–160
Publisher
Wolters Kluwer
Publication Date
2 2023
DOI
10.1097/shk.0000000000002051
ISSN
1073-2322