Journal article
XEN-D0501, a Novel Transient Receptor Potential Vanilloid 1 Antagonist, Does Not Reduce Cough in Patients with Refractory Cough
Abstract
RATIONALE: Heightened cough responses to inhaled capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, are characteristic of patients with chronic cough. However, previously, a TRPV1 antagonist (SB-705498) failed to improve spontaneous cough frequency in these patients, despite small reductions in capsaicin-evoked cough.
OBJECTIVES: XEN-D0501 (a potent TRPV1 antagonist) was compared with SB-705498 in preclinical studies to …
Authors
Belvisi MG; Birrell MA; Wortley MA; Maher SA; Satia I; Badri H; Holt K; Round P; McGarvey L; Ford J
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 196, No. 10, pp. 1255–1263
Publisher
American Thoracic Society
Publication Date
November 15, 2017
DOI
10.1164/rccm.201704-0769oc
ISSN
1073-449X