Journal article
Control of mitochondrial gene expression in the aging rat myocardium
Abstract
Aging induces complex changes in myocardium bioenergetic and contractile properties. Using F344BNF(1) rats, we examined age-dependent changes in myocardial bioenergetic enzymes (catalytic activities and transcript levels) and mRNA levels of putative transcriptional regulators of bioenergetic genes. Very old rats (35 months) showed a 22% increase in ventricular mass with no changes in DNA or RNA per gram. Age-dependent cardiac hypertrophy was …
Authors
LeMoine CMR; McClelland GB; Lyons CN; Mathieu-Costello O; Moyes CD
Journal
Biochemistry and Cell Biology, Vol. 84, No. 2, pp. 191–198
Publisher
Canadian Science Publishing
Publication Date
April 1, 2006
DOI
10.1139/o05-169
ISSN
0829-8211