Acclimation to hypoxia increases carbohydrate use during exercise in high-altitude deer mice

The low O₂ experienced at high altitude is a significant challenge to effective aerobic locomotion, as it requires sustained tissue O₂ delivery in addition to the appropriate allocation of metabolic substrates. Here, we tested whether high- and low-altitude deer mice (Peromyscus maniculatus) have evolved different acclimation responses to hypoxia with respect to muscle metabolism and fuel use during submaximal exercise. Using F₁ generation …