Improved method for the stereospecific 1H‐NMR assignments in collagen‐like triple‐helices

An improved model‐based method for the stereospecific assignment of prochiral centers in collagen‐like triple‐helical molecules is introduced. Using the concepts of reporter atoms and of ensemble NOEs, the proposed methodology extracts the stereochemical information contained in the chiral elements of triple‐helices and transfers it to prochiral centers with nondegenerate proton resonances. The improved approach has been successfully validated …