Journal article
Solid-phase Suzuki cross-coupling reactions using a phosphine ligand based on a phospha-adamantane framework
Abstract
The use of a catalyst system based on Pd2dba3·CHCl3 and 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phenyl-6-phospha-adamantane allows for Suzuki coupling aryl halides with an array of boronic acids on a solid-phase platform. The reactions can be carried out at room temperature with low palladium loadings in high yields.
Authors
Ohnmacht SA; Brenstrum T; Bleicher KH; McNulty J; Capretta A
Journal
Tetrahedron Letters, Vol. 45, No. 29, pp. 5661–5663
Publisher
Elsevier
Publication Date
July 2004
DOI
10.1016/j.tetlet.2004.05.110
ISSN
0040-4039