Direct Oral Anticoagulant Reversal for Management of Bleeding and Emergent Surgery

Direct oral anticoagulants (DOACs, or non-vitamin K antagonist oral anticoagulants [NOACs]) include dabigatran, a direct thrombin inhibitor, and factor Xa inhibitors (rivaroxaban, apixaban, edoxaban, betrixaban). They have largely replaced vitamin K anticoagulants (VKAs) in clinical practice. Their overall safety profile concerning bleeding appears to be at least equivalent, if not superior, to VKAs. However, the lack of a specific reversal …