Journal article
The synthesis of corticosteroid–carborane esters for the treatment of rheumatoid arthritis via boron neutron capture synovectomy
Abstract
Two corticosteroid–carborane esters were synthesized through the use of a BOP-Cl promoted esterification. The steroid–carborane conjugates are designed to selectively deliver boron to arthritic tissue for boron neutron capture synovectomy, a new therapeutic approach for rheumatoid arthritis.
Authors
Valliant JF; Schaffer P; Britten JF; Davison A; Jones AG; Yanch JC
Journal
Tetrahedron Letters, Vol. 41, No. 9, pp. 1355–1358
Publisher
Elsevier
Publication Date
February 2000
DOI
10.1016/s0040-4039(99)02292-3
ISSN
0040-4039