Preparation and evaluation of reagents for tagging amino and thiol groups with fluorous stannanes. A convenient method for producing radioiodinated compounds in high effective specific activity

Abstract Building on the previously reported fluorous labeling strategy (FLS), a new approach for preparing molecular imaging and therapy agents derived from radioiodine in high purity without the need to employ HPLC was developed. A series of novel reagents containing a fluorous arylstannane, including fluorous benzaldehydes ( 1a/b ) and an aryl‐iodoacetamide ( 2 ), were prepared so that the FLS could be used to label and purify targeting …