Abstract B17: High expression of the transcription factor Kaiso correlates with aggressive breast cancers (BC) and racial disparity in BC outcomes in women of African ancestry

Abstract The highly metastatic triple negative breast cancers (TNBC) lack expression of estrogen-receptor (ER), progesterone-receptor (PR) and human epidermal growth factor receptor-2 (HER2), and thus have limited patient treatment options and prognosis. Intriguingly TNBC is most prevalent in young women of African Ancestry (WAA) who, despite having lower BC incidence rates than Caucasian women, have higher mortality rates. …