Journal article
An HLA-G/SPAG9/STAT3 axis promotes brain metastases
Abstract
Brain metastases (BM) are the most common brain neoplasm in adults. Current BM therapies still offer limited efficacy and reduced survival outcomes, emphasizing the need for a better understanding of the disease. Herein, we analyzed the transcriptional profile of brain metastasis initiating cells (BMICs) at two distinct stages of the brain metastatic cascade-the "premetastatic" or early stage when they first colonize the brain and the …
Authors
Bassey-Archibong BI; Chokshi CR; Aghaei N; Kieliszek AM; Tatari N; McKenna D; Singh M; Subapanditha MK; Parmar A; Mobilio D
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 120, No. 8,
Publisher
Proceedings of the National Academy of Sciences
Publication Date
February 21, 2023
DOI
10.1073/pnas.2205247120
ISSN
0027-8424