The effects of altered expression of the Keap1/CncC pathway on the secretion of fluid and salicylate by Malpighian tubules of Drosophila melanogaster

Abstract The K eap1‐ N rf2 pathway is a major upstream regulator of xenobiotic detoxification. In D rosophila melanogaster M eigen, targeted expression of K eap1 and CncC (the latter the orthologue of human N rf2) in the M alpighian (renal) tubules is known to confer resistance to lethal doses of the pesticide malathion, which is metabolized into organic anions. Dietary exposure to organic anions such as salicylate (10 m m ) causes increases …