Characterization of transepithelial transport of salicylate by the Malpighian tubules of Drosophila melanogaster and the effects of changes in fluid secretion rate

Abstract A radioisotope tracer technique is used to study mechanisms and regulation of transepithelial transport of the plant allelochemical salicylate by the Malpighian tubules of Drosophila melanogaster . Transepithelial transport of salicylate is nearly abolished in Na + ‐free saline, and inhibited by ouabain, low K + or K + ‐free bathing saline. In addition, the carboxylates probenecid, unlabelled salicylate, fluorescein, and p …