Journal article
PEA3, AP-1, and a unique repetitive sequence all are involved in transcriptional regulation of the breast cancer-associated gene, mammaglobin
Abstract
The breast cancer-associated gene mammaglobin is a member of the secretoglobin protein family and has demonstrated its utility as a breast cancer marker. However, the transcriptional regulation of mammaglobin has not been well-characterized. In this report, we used luciferase reporter assays to identify the 200 bp directly 5’ of the transcriptional start site as the minimal promoter region of mammaglobin. Sequence scanning indicated that two …
Authors
Hesselbrock DR; Kurpios N; Hassell JA; Watson MA; Fleming TP
Journal
Breast Cancer Research and Treatment, Vol. 89, No. 3, pp. 289–296
Publisher
Springer Nature
Publication Date
February 2005
DOI
10.1007/s10549-004-2622-z
ISSN
0167-6806
Fields of Research (FoR)
Medical Subject Headings (MeSH)
BreastBreast NeoplasmsElectrophoretic Mobility Shift AssayFemaleGene Expression Regulation, NeoplasticHumansLuciferasesMammaglobin AMutationNeoplasm ProteinsPromoter Regions, GeneticRepetitive Sequences, Nucleic AcidTranscription Factor AP-1Transcription FactorsTranscription Initiation SiteTranscription, GeneticTumor Cells, CulturedUteroglobin