Journal article
Antihypertensive effects of perindopril treatment in adult spontaneously hypertensive rats.
Abstract
OBJECTIVE: To determine the effect of perindopril treatment and treatment withdrawal in the prevention of hypertension in adult male spontaneously hypertensive rats (SHR).
ANIMALS AND METHODS: Beginning at 15 weeks of age, male SHR were treated with either distilled water (control) or different daily dosages of perindopril (1, 2 or 4 mg/kg) by gavage for 10 weeks, followed by 10 weeks of treatment withdrawal. Systolic blood pressure, heart rate …
Authors
Lee RM; Lu M; Gillies L; Werstiuk ES
Journal
Canadian Journal of Cardiology, Vol. 13, No. 9, pp. 831–835
Publication Date
September 1997
ISSN
0828-282X