Opioid Reduction and Enhanced Recovery in Orthopaedic Surgery (OREOS): A Protocol for a Feasibility Randomized Controlled Trial in Knee Replacement Patients

Background: Knee arthritis is a leading cause of limited function and long-term disability in older adults. Despite a technically successful total knee arthroplasty (TKA), around 20% of patients continue to have persisting pain with reduced function, and low quality of life. Many of them continue using opioids for pain control, which puts them at risk for potential long-term adverse effects such as dependence, overdose, and risk of falls. …