Sex, age and generation effects on genome-wide linkage analysis of gene expression in transformed lymphoblasts

BackgroundMany traits differ by age and sex in humans, but genetic analysis of gene expression has typically not included them in the analysis.MethodsWe used Genetic Analysis Workshop 15 Problem 1 data to determine whether gene expression in lymphoblasts showed differences by age and/or sex using generalized estimating equations (GEE). We performed quantitative trait linkage analysis of these genes including age and sex as covariates to …