Journal article
The impact of category, cytopathology and cytogenetics on development and progression of clonal and malignant myeloid transformation in inherited bone marrow failure syndromes
Abstract
Inherited bone marrow failure syndromes are a group of rare, heterogeneous genetic disorders with a risk of clonal and malignant myeloid transformation including clonal marrow cytogenetic abnormalities, myelodysplastic syndrome and acute myeloid leukemia. The clinical characteristics, risk classification, prognostic factors and outcome of clonal and malignant myeloid transformation associated with inherited bone marrow failure syndromes are …
Authors
Cada M; Segbefia CI; Klaassen R; Fernandez CV; Yanofsky RA; Wu J; Pastore Y; Silva M; Lipton JH; Brossard J
Journal
Haematologica, Vol. 100, No. 5, pp. 633–642
Publisher
Ferrata Storti Foundation (Haematologica)
Publication Date
May 1, 2015
DOI
10.3324/haematol.2014.117457
ISSN
0390-6078
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdolescentAdultAnemia, AplasticBone MarrowBone Marrow DiseasesBone Marrow Failure DisordersCanadaCell Transformation, NeoplasticChildChild, PreschoolChromosome AberrationsClonal EvolutionCytogenetic AnalysisDisease ProgressionHemoglobinuria, ParoxysmalHumansInfantInfant, NewbornKaplan-Meier EstimateLeukemia, Myeloid, AcutePatient Outcome AssessmentPrognosisRegistriesRiskYoung Adult