Journal article
Risks of congenital malformations in offspring exposed to valproic acid in utero: A systematic review and cumulative meta‐analysis
Abstract
Despite extensive research efforts over decades, the teratogenic profile of valproic acid (VPA) remains obscure. We performed cumulative and conventional meta-analyses of cohort studies to determine the time profiles of signal emergence of VPA-associated congenital malformations (CMs) and to define risk estimates of each of the CMs. Fifty-nine studies were identified and analyzed. We found that the significant risk signals began to emerge over …
Authors
Tanoshima M; Kobayashi T; Tanoshima R; Beyene J; Koren G; Ito S
Journal
Clinical Pharmacology & Therapeutics, Vol. 98, No. 4, pp. 417–441
Publisher
Wiley
Publication Date
October 2015
DOI
10.1002/cpt.158
ISSN
0009-9236