Journal article
Multivariate Meta-Analysis of Genetic Association Studies: A Simulation Study
Abstract
In a meta-analysis with multiple end points of interests that are correlated between or within studies, multivariate approach to meta-analysis has a potential to produce more precise estimates of effects by exploiting the correlation structure between end points. However, under random-effects assumption the multivariate estimation is more complex (as it involves estimation of more parameters simultaneously) than univariate estimation, and …
Authors
Neupane B; Beyene J
Journal
PLOS ONE, Vol. 10, No. 7,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0133243
ISSN
1932-6203