Influence of concurrent medications on outcomes of men with prostate cancer included in the TAX 327 study

OBJECTIVES: The TAX 327 trial was pivotal in establishing docetaxel in castration refractory metastatic prostate cancer. Various commonly prescribed and over-the-counter co-administered medications are thought to exhibit anti-neoplastic properties and/or could potentially have pharmacokinectic interactions with docetaxel lessening the effectiveness of chemotherapy. METHODS: To examine the effect of on prostate cancer outcomes within this trial, …