Journal article
Biphasic effect of D-2 agonist quinpirole on locomotion and movements
Abstract
The effects of the D-2 agonist quinpirole on forward progression, and on vertical and lateral movements, were measured for 2 h in rats injected with either saline, 0.03, 0.125, 0.5 or 8 mg/kg of the drug. Results showed that the drug had a biphasic effect: the lowest dose decreased and the high doses increased the amount of locomotion and of movement. The decrease in activity produced by the low dose had its onset within minutes after …
Authors
Eilam D; Szechtman H
Journal
European Journal of Pharmacology, Vol. 161, No. 2-3, pp. 151–157
Publisher
Elsevier
Publication Date
February 1989
DOI
10.1016/0014-2999(89)90837-6
ISSN
0014-2999