Journal article
Dynamics of behavioral sensitization induced by the dopamine agonist quinpirole and a proposed central energy control mechanism
Abstract
The study characterizes the process of sensitization induced by intermittent administrations of quinpirole (0.5 mg/kg) in rats in a large open field. Sensitization was found to be self-limiting, with all measures of behavior reaching a plateau after the tenth twice-weekly injection. Kinetics of sensitization were a simple hyperbolic function of the number of drug injections for some measures (speed of locomotion, length of locomotor bouts) but …
Authors
Szechtman H; Talangbayan H; Canaran G; Dai H; Eilam D
Journal
Psychopharmacology, Vol. 115, No. 1-2, pp. 95–104
Publisher
Springer Nature
Publication Date
June 1994
DOI
10.1007/bf02244757
ISSN
0033-3158