Journal article
Quinpirole and 8-OH-DPAT induce compulsive checking behavior in male rats by acting on different functional parts of an OCD neurocircuit
Abstract
This study investigated whether the serotonin 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) can induce compulsive checking in a large open field, as does the dopamine D2/D3 receptor agonist quinpirole. To induce compulsive checking, male rats were exposed to eight injections of either 8-OH-DPAT (1 mg/kg), quinpirole (0.2 mg/kg), or saline. Subsequently, to assess cross-sensitization, rats received an acute …
Authors
Alkhatib AH; Dvorkin-Gheva A; Szechtman H
Journal
Behavioural Pharmacology, Vol. 24, No. 1, pp. 65–73
Publisher
Wolters Kluwer
Publication Date
February 2013
DOI
10.1097/fbp.0b013e32835d5b7a
ISSN
0955-8810
Fields of Research (FoR)
Medical Subject Headings (MeSH)
8-Hydroxy-2-(di-n-propylamino)tetralinAnimalsBehavior, AnimalBrainCompulsive BehaviorDisease Models, AnimalDopaminergic NeuronsDrug InteractionsMaleNerve Tissue ProteinsNeuronsObsessive-Compulsive DisorderQuinpiroleRandom AllocationRatsRats, Long-EvansSerotonergic NeuronsSerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT2 Receptor AgonistsSerotonin 5-HT3 Receptor AgonistsSerotonin Receptor AgonistsSpatial Behavior