Journal article
The role of immune system maturation in gut-microbiota-brain axis communication
Abstract
Recent studies have shown differences in behavior and brain biochemistry between germ-free (GF) and conventional mice. In this study we investigated the role of immune system maturation in altered mouse behaviour after bacterial colonization. Swiss Webster GF mice were treated with: saline, complex microbiota, permanent colonizer E. coli JM83 and transient colonizer E. coli HA107 (a mutant form of E. coli JM83). Behaviour was assessed using …
Authors
Philip V; Lu J; Galipeau HJ; Verdu EF; McCoy KD; Langella P; Macpherson AJ; Hapfelmeier S; Surette MG; Collins SM
Journal
Brain Behavior and Immunity, Vol. 49, , pp. e36–e37
Publisher
Elsevier
Publication Date
October 2015
DOI
10.1016/j.bbi.2015.06.140
ISSN
0889-1591