Abstract 134: Kidney and Blood Pressure Abnormalities, and Cardiac Enlargement Accompany Moderate Coronary Artery Atherosclerosis in Western Diet Fed SR-BI/LDLR Double Knockout Mice

Mice lacking the HDL receptor, SR-BI, are susceptible to spontaneous or diet-inducible occlusive coronary artery (CA) atherosclerosis and myocardial infarction (MI) in the context of absence, or reduced expression of apoE, respectively. Our lab has generated mice lacking both SR-BI and the LDL receptor (dKO mice). When fed diets that are very high in cholesterol, dKO mice develop rapid CA atherosclerosis and large transmural MIs, and exhibit …