Abstract 50: High-Density Lipoprotein Protects Macrophages Against Apoptosis in a PDZK1-Dependent Manner

Macrophage apoptosis contributes to the formation of necrotic cores in atherosclerotic plaques, increasing the risk of plaque rupture, leading to clinical heart attack. Previous work from our group showed that HDL is able to protect macrophages against apoptosis, and that such protection requires HDL’s receptor protein scavenger receptor class B, type I (SR-BI). In this study, we hypothesize that this protection requires not only SR-BI, but …