Abstract 284: A Deficiency in the HDL Receptor SR-BI Attenuates Atherosclerotic Plaque Regression in ApoE-Hypomorphic Mice

A deficiency in the HDL receptor, SR-BI, results in accelerated arterial plaque development in ApoE-R61 hypomorphic (“Hypo-E”) mice, however the effect of a lack of SR-BI on atherosclerotic plaque regression is unknown.To explore the role of SR-BI in the regression of arterial atherosclerosis in the Hypo-E mouse model, SR-BI-deficient/Hypo-E (SR-BI-deficient) or SR-BI-expressing/Hypo-E (control) mice were fed high-cholesterol, high-fat diets …