Journal article
SREBP‐1 Mediates Angiotensin II‐induced TGFβ Upregulation in Kidney Mesangial Cells
Abstract
Angiotensin II (Ang II) is a key determinant of the progression of kidney disease of diverse etiology. Mesangial cells (MC) contribute importantly to the accumulation of glomerular matrix proteins and hence glomerular sclerosis. We recently demonstrated a role for the transcription factor sterol regulatory element binding protein (SREBP‐1), best known for its regulation of lipid metabolism, in high glucose fibrotic responses in MC. Here we …
Authors
Wang T; Gao B; Uttarwar L; Krepinsky JC
Journal
The FASEB Journal, Vol. 27, No. S1, pp. 601.8–601.8
Publisher
Wiley
Publication Date
April 2013
DOI
10.1096/fasebj.27.1_supplement.601.8
ISSN
0892-6638