Journal article
A33 ROLE OF SEROTONIN-AUTOPHAGY AXIS IN INTESTINAL INFLAMMATION
Abstract
Serotonin (5-hydroxytryptamine; 5-HT) is an important enteric signalling molecule that regulates physiological and pathological processes of the gut. Enterochromaffin (EC) cells are the main producer of 5-HT in gut, and tryptophan hydroxylase 1 (Tph1) is the rate-limiting enzyme of 5-HT biosynthesis in EC cells. Changes in EC cell number and 5-HT content are detected in inflammatory bowel disease (IBD) and in experimental colitis. Tph1-/- mice …
Authors
Haq S; Wang H; Kim JJ; Steinberg G; Brumell J; Khan WI
Journal
Journal of the Canadian Association of Gastroenterology, Vol. 2, No. Supplement_2, pp. 66–67
Publisher
Oxford University Press (OUP)
Publication Date
March 15, 2019
DOI
10.1093/jcag/gwz006.032
ISSN
2515-2084