Journal article
Abstract 19: Deletion of Myeloid GSK3α Attenuates Atherosclerosis and Promotes an M2 Macrophage Phenotype
Abstract
Objective: Glycogen synthase kinase (GSK)-3α/β has been implicated in the pathogenesis of diseases including diabetes, cancer, Alzheimer’s and atherosclerosis. The tissue and homolog specific functions of GSK3α and β in atherosclerosis are unknown. This study examines the effect of hepatocyte or myeloid cell specific deletion of GSK3α or GSK3β on atherosclerosis in LDLR-/- mice. Approach and results: We ablated GSK3α or GSK3β expression in …
Authors
McAlpine C; Huang A; Emdin A; Banko N; Beriault D; Shi Y; Werstuck G
Journal
Arteriosclerosis Thrombosis and Vascular Biology, Vol. 35, No. suppl_1,
Publisher
Wolters Kluwer
Publication Date
5 2015
DOI
10.1161/atvb.35.suppl_1.19
ISSN
1079-5642