Journal article
Inhibition of spawning in zebrafish (Danio rerio): Adverse outcome pathways of quinacrine and ethinylestradiol
Abstract
This study determined the effects of the estrogen receptor agonist ethinylestradiol (EE2) and the phospholipase A2 inhibitor quinacrine (QUIN) on the pathways controlling follicular development, steroidogenesis, oocyte maturation, ovulation and spawning success in adult zebrafish. Both EE2 and QUIN inhibited spawning but did so through different mechanisms. EE2 affected follicular development (reduced ovarian size and reduction in the …
Authors
Cosme MM; Lister AL; Van Der Kraak G
Journal
General and Comparative Endocrinology, Vol. 219, , pp. 89–101
Publisher
Elsevier
Publication Date
August 2015
DOI
10.1016/j.ygcen.2015.01.013
ISSN
0016-6480