Journal article
Sounding the alarmins—The role of alarmin cytokines in asthma
Abstract
The alarmin cytokines thymic stromal lymphopoietin (TSLP), interleukin (IL)-33, and IL-25 are epithelial cell-derived mediators that contribute to the pathobiology and pathophysiology of asthma. Released from airway epithelial cells exposed to environmental triggers, the alarmins drive airway inflammation through the release of predominantly T2 cytokines from multiple effector cells. The upstream positioning of the alarmins is an attractive …
Authors
Gauvreau GM; Bergeron C; Boulet L; Cockcroft DW; Côté A; Davis BE; Leigh R; Myers I; O'Byrne PM; Sehmi R
Journal
Allergy, Vol. 78, No. 2, pp. 402–417
Publisher
Wiley
Publication Date
February 2023
DOI
10.1111/all.15609
ISSN
0001-5148