Journal article
Are U‐shaped relationships between risk factors and outcomes artifactual?
Abstract
BACKGROUND: The objective of this study was to evaluate whether the observed nadir in a U- or J-shaped relationship between a particular risk factor and a future health outcome is a function of the distribution of the risk factor in the sample being analyzed.
METHODS: Data from the ORIGIN trial were used to assess the relationship between three risk factors (weight, systolic blood pressure, and serum insulin) and the hazard of a major …
Authors
Shah R; Thabane L; Gerstein HC
Journal
Journal of Diabetes, Vol. 14, No. 12, pp. 815–821
Publisher
Wiley
Publication Date
December 2022
DOI
10.1111/1753-0407.13335
ISSN
1753-0393