Journal article
RETRACTED ARTICLE:Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice
Abstract
BackgroundHuman genetic disorders and transgenic mouse models have shown that
mitochondrial DNA (mtDNA) mutations and telomere dysfunction instigate the aging
Authors
Safdar A; Khrapko K; Flynn JM; Saleem A; De Lisio M; Johnston APW; Kratysberg Y; Samjoo IA; Kitaoka Y; Ogborn DI
Journal
Skeletal Muscle, Vol. 6, No. 1,
Publisher
Springer Nature
Publication Date
December 2015
DOI
10.1186/s13395-016-0075-9
ISSN
2044-5040
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsApoptosisCells, CulturedDNA Polymerase gammaDNA RepairDNA, MitochondrialDNA-Directed DNA PolymeraseGenotypeLife ExpectancyMice, Inbred C57BLMice, KnockoutMice, Mutant StrainsMitochondria, HeartMitochondria, MuscleMuscle ContractionMuscle, SkeletalMutationMyocardial ContractionMyocardiumOrganelle BiogenesisOxidative StressPhenotypeProtein TransportTelomereTelomere HomeostasisTime FactorsTransfectionTumor Suppressor Protein p53