Journal article
cAMP-dependent allostery and dynamics in Epac: an NMR view
Abstract
Epac (exchange protein directly activated by cAMP) is a critical cAMP receptor, which senses cAMP and couples the cAMP signal to the catalysis of guanine exchange in the Rap substrate. In the present paper, we review the NMR studies that we have undertaken on the CBD (cyclic-nucleotide-binding domain) of Epac1. Our NMR investigations have shown that cAMP controls distal autoinhibitory interactions through long-range modulations in dynamics. …
Authors
Selvaratnam R; Akimoto M; VanSchouwen B; Melacini G
Journal
Biochemical Society Transactions, Vol. 40, No. 1, pp. 219–223
Publisher
Portland Press
Publication Date
February 1, 2012
DOI
10.1042/bst20110628
ISSN
0300-5127