Journal article
A Tool Set to Map Allosteric Networks through the NMR Chemical Shift Covariance Analysis
Abstract
Allostery is an essential regulatory mechanism of biological function. Allosteric sites are also pharmacologically relevant as they are often targeted with higher selectivity than orthosteric sites. However, a comprehensive map of allosteric sites poses experimental challenges because allostery is driven not only by structural changes, but also by modulations in dynamics that typically remain elusive to classical structure determination …
Authors
Boulton S; Akimoto M; Selvaratnam R; Bashiri A; Melacini G
Journal
Scientific Reports, Vol. 4, No. 1,
Publisher
Springer Nature
DOI
10.1038/srep07306
ISSN
2045-2322