Journal article
The Effects of Hyperglycemia on Early Endothelial Activation and the Initiation of Atherosclerosis
Abstract
It is well established that patients with diabetes have an increased risk of developing atherosclerotic cardiovascular disease. The earliest detectable sign of atherosclerosis initiation is endothelial cell activation. Activated endothelial cells express adhesion proteins, P-selectin, E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1, which function to recruit monocytes to the subendothelial layer. This study …
Authors
Mastrogiacomo L; Ballagh R; Venegas-Pino DE; Kaur H; Shi P; Werstuck GH
Journal
American Journal Of Pathology, Vol. 193, No. 1, pp. 121–133
Publisher
Elsevier
Publication Date
January 2023
DOI
10.1016/j.ajpath.2022.09.004
ISSN
0002-9440