Sample preconcentration with chemical derivatization in capillary electrophoresis Capillary as preconcentrator, microreactor and chiral selector for high-throughput metabolite screening

New strategies for integrating sample pretreatment with chemical analyses under a single format is required for rapid, sensitive and enantioselective analyses of low abundance metabolites in complex biological samples. Capillary electrophoresis (CE) offers a unique environment for controlling analyte/reagent band dispersion and electromigration properties using discontinuous electrolyte systems. Recent work in our laboratory towards developing …