Journal article
Comprehensive Plasma Thiol Redox Status Determination for Metabolomics
Abstract
Thiol homeostasis plays an important role in human health and aging by regulation of cellular responses to oxidative stress. Due to major constraints that hamper reliable plasma thiol/disulfide redox status assessment in clinical research, we introduce an improved strategy for comprehensive thiol speciation using capillary electrophoresis-electrospray ionization-mass spectrometry (CE-ESI-MS) that overcomes sensitivity, selectivity and dynamic …
Authors
D’Agostino LA; Lam KP; Lee R; Britz-McKibbin P
Journal
Journal of Proteome Research, Vol. 10, No. 2, pp. 592–603
Publisher
American Chemical Society (ACS)
Publication Date
February 4, 2011
DOI
10.1021/pr100771g
ISSN
1535-3893